The OPGS solutions to the challenge of reactivating acetylcholinesterase

1. VERSATILE ANTIDOTES against multiple neurotoxic agents

OPGS Pharma, based on CNRS-initiated research, is developing a new generation of versatile antidotes against organophosphorus chemical warfare and pesticides.

OPGS lead compound and its back-up have demonstrated a much superior in vitro activity against all tested neurotoxic poisons and pesticides to that of currently prescribed compounds (pralidoxime/obidoxime).

1. ANTIDOTES THAT EFFECTIVELY CROSS THE BLOOD-BRAIN BARRIER AND HAVE THE POTENTIAL TO PROTECT THE CNS FUNCTIONS

As mentioned below, OPGS lead and back-up have the ability to cross the blood-brain barrier, much more effectively than pralidoxime and even more than HI-6 and obidoxime.

As most poisons have direct CNS toxicity, this represent a unique feature of significant clinical relevance.